Anthropic’s Claude models now sit alongside OpenAI’s inside Microsoft 365 Copilot, Copilot Studio and Power Platform. For most commercial customers they are switched on by default. For tenants in the UK, EU and EFTA they are not: the setting starts at Off and stays there until an administrator turns it on.
That default is a sensible one, because enabling Claude changes where your prompts may be processed and whose contract governs them. This guide explains what Microsoft’s own documentation says, why UK data residency is the sticking point, and how to make a documented decision rather than letting the setting drift. If you are weighing Microsoft 365 AI automation or AI governance for SMEs, this is a ten-minute decision that deserves to be made on purpose.
Microsoft’s documentation, Anthropic models in Microsoft 365 Copilot, sets out the position. Anthropic has been onboarded as a Microsoft subprocessor, which means that for standard models the Microsoft Product Terms, the Data Protection Addendum and Enterprise Data Protection apply, not a separate Anthropic contract. The models appear in Microsoft Copilot, Researcher, Copilot Studio, Power Platform and Copilot in Microsoft 365 apps. In Copilot Studio, builders pick the model when they create an agent, and users can choose Claude in features such as Researcher.
The regional split is the important part:
| Region | Anthropic models by default |
|---|---|
| Most commercial tenants | On |
| UK, EU and EFTA tenants | Off (the admin view shows “No users”) |
| GCC High, DoD and sovereign clouds | Not available |
Two further details matter. First, if you opted in earlier under Anthropic’s own commercial terms, Microsoft says you must opt in again under the new arrangement. Second, since 3 April 2026 there has been a separate admin setting, Copilot in Microsoft 365 apps with Anthropic models, which can make Anthropic the default model in Copilot in the Microsoft 365 apps for UK, EU and EFTA tenants. Enabling the subprocessor and choosing the default are separate decisions.
This is where UK businesses need to slow down. Microsoft states that Anthropic models in Copilot, Researcher, Copilot Studio, Power Platform and Copilot in Microsoft 365 apps are currently excluded from the EU Data Boundary and, where applicable, from in-country processing commitments. An independent UK consultancy write-up reaches the same conclusion and recommends checking Microsoft’s subprocessor documentation on the day you decide, because boundary coverage may change.
Separately, Microsoft has been rolling out in-country processing for Copilot interactions. Its revised plan, last updated on 3 April 2026, lists the United Kingdom among the countries due to receive it by the end of 2026. Microsoft describes the offer as aimed mainly at government and highly regulated organisations. If your contracts, your regulator or your customers rely on that commitment, then enabling Claude for a user means that user’s Claude-routed prompts sit outside it.
In practice this is a scoping decision, not a yes-or-no one. Enable Claude for a named group doing work where the benefit is clear and the data is low risk, and leave it off for teams whose obligations depend on the boundary. The admin centre lets you assign access to specific users or Microsoft Entra ID groups.
Microsoft draws a hard line between standard Anthropic models and those labelled Anthropic models with Data Retention. Its page lists some of the newest Claude models in this second category. They are off by default for every tenant, including regions where other Anthropic models are on, and nobody has access until an administrator explicitly opts in and chooses who can use them.
The terms differ materially. For these models Anthropic acts as an independent processor under its own Commercial Terms and Data Protection Addendum, not as a Microsoft subprocessor. Microsoft says Anthropic stores most inputs and outputs for up to 30 days, content flagged by its trust and safety classifiers may be kept for up to two years, and classification scores for up to seven years. Anthropic does not use retained data for training without express permission. Microsoft also says some models in the newest class may be offered under the standard subprocessor terms for certain organisations, so check which label a specific model carries before you enable anything.
Opting in to standard Anthropic models does not switch these on. Keep the two decisions separate in your records.
Model choice is rarely the reason a Copilot rollout succeeds or fails. The usual causes are permissions, data quality and adoption. Our oversharing guide covers the first, and it matters more than which model answers the prompt. Claude inside Copilot is worth testing where you already have a reason to prefer it, such as longer document analysis in Researcher, or where a Copilot Studio agent benefits from a different model. It is not a reason to rush.
It also does not replace a bespoke build. If you need an audit trail, your own approval steps or a fixed processing region, a purpose-built tool on the Claude API, with the region you choose, may fit better. See Copilot versus custom AI and our Claude API buyer’s guide for where that line sits.
This is the order I would work in. For a small tenant it is an afternoon, not a project.
If you later change your mind, the same page has an option to disable Anthropic as a Microsoft subprocessor. Microsoft notes some features may become unavailable, and you can re-enable it afterwards.
An approved-tools list that says “Copilot” no longer tells staff enough. Your AI usage policy should now say which models are enabled, for whom, and which data types are out of bounds for them. Our AI usage policy how-to and the free policy template give you the structure, and the AI governance framework shows where a model-level decision like this one belongs in your register of approved tools.
Sources: Microsoft Learn, Anthropic models in Microsoft Online Services; Microsoft Copilot blog, in-country data processing for Microsoft 365 Copilot (original November 2025, revised 3 April 2026); Talk Think Do, Claude in Microsoft 365 Copilot: UK checks (August 2026). Microsoft changes these settings often, so check the current documentation before you act.
I help UK SMEs review their Copilot settings, scope model access by group, and document the decision so it stands up to a customer or auditor question. Get in touch or book a 30-minute call.
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